CV Clifford George Kentros

email: clifford.kentros@ntnu.no

 

Researcher Unique ID:

ORCID: https://orcid.org/0000-0003-3850-3829

Rearchgate.net: Clifford Kentros                      

 

  • EDUCATION

 

1985-1988:B.A. in Biology (1988), New College, Sarasota, Florida

1988-1991:MS.c in Cell and Molecular Biology (1991), Sackler Institute, New York University (NYU) Medical Center

1991-1996: Ph.D in Physiology and Neuroscience, (1996); NYU Medical Center.

I started in cell and molecular biology but switched to neuroscience, completing my PhD thesis on potassium channels in Bernardo Rudy’s lab at NYU. My postdoctoral work in the Kandel lab on the mechanisms of learning and memory and in my own lab focused upon the relationship between the spatial firing of neurons of the hippocampus and associated cortices and learning and memory.  More recently, we apply molecular biology techniques to generate tools systems neurophysiology by making transgenic and viral tools specifically designed to serve systems neuroscience, rather than molecular questions.

                           

 

  • CURRENT POSITIONS:

 

2013- Professor of Medicine, Kavli Institute for Systems Neuroscience, NTNU, Trondheim, Norway

2013- Associate Research Professor, University of Oregon, USA

 

  • PREVIOUS POSITIONS:

 

2010-2013 - Associate Professor of Psychology with tenure, University of Oregon, USA

2004-2010 - Assistant Professor of Psychology, University of Oregon, USA

2002-2004 – Research Scientist IV, New York State Psychiatric Institute, New York, USA

2000-2002 – Associate Research Scientist, New York State Psychiatric Institute, New York, NY USA & Columbia University

1996-2000 – Postdoctoral fellow, Columbia University College of Physicians and Surgeons, New York NY

1996-1998 - Postdoctoral fellow at SUNY Downstate Medical Center, Brooklyn, NY

1991-1996 - PhD student, Department of Physiology and Neuroscience, NYU Medical Center

 

  • FELLOWSHIPS AND AWARDS

 

1995 Grass Foundation Fellow at the Marine Biological Laboratory, Woods Hole, MA

2005 Medical Research Foundation of Oregon Young Investigator Award

2015 Royal Academy of Arts and Letters, Member,

2016: Norwegian Neuroscience Society,

2016: Society for Neuroscience,

2016: DKNVS, Det Kongelige Norske Vitenskapers Selskap

2016: Olav Thon Foundation, Nordic Alzheimer’s Research Award

2016: Norwegian Research Foundation (Toppforsk) Research Award,

2015: Member, Royal Academy of Arts and Letters, Trondheim, Norway

2015: FENS/Kavli Network of Excellence

2015: Federation of European Neuroscience

2015: NIMH, Special Emphasis panel ZMH1 ERB-L Brain Initiative, Member

 

  • SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS

Postdoctoral:

Robin Hayman (now a postdoc at University College, London),

Stepan Kubik (now a PI at the Czech National Academy of Sciences),

Ted Dumas (now Associate Professor. of Psychology at George Mason University),

Aldis Weible (now an Associate Research Scientist at the University of Oregon),

Nils Borgesius,(now at Donders Institute for Brain, Cognition and Behavior at Radbound University, The Netherlands.)

Stefan Blankvoort, (now a Researcher at the Kavli Institute for Systems Neuroscience, NTNU, Norway)

Rajeev Nair, ( now Manager/Researcher Viral Vector Core, Kavli Institute/CNC)

Currently working with Lucie Descamps, Oscar Michael Thornton Chadney, Joachim Schweder Grimstvedt, Annika Utz, Benjamin kanter, Christine Lykken at NTNU.

 

Graduate Students:  

Caitlin Monaghan (now in the Hasselmo lab, Boston University)

David Rowland (now postdoc in the Moser lab, NTNU)

Devdeep Aikath (now a postdoc at Baylor College of Medicine)

Leah DeBlander, (now Researcher at the Department of Biology, University of OR)

Christy Lykken, (now finishing her PhD at the Kavli Institute of Systems Neuroscience, NTNU).

Benjamin Kanter, (now finishing his PhD at the Kavli Institute of Systems Neuroscience, NTNU.)

Christin Berndtsson. (now Coordinator of the NRSN at the Kavli Institute of Systems Neuroscience, NTNU.)

Vilde Aamodt Kveim, (now taking her PhD at Basel University Biozentrum in Switzerland.)

Marcus Sandbukt Flatset, (now finishing his Master's at the Kavli Institute of Systems Neuroscience, NTNU.)

Joachim Schweder Grimstvedt. (now starting on his PhD at the Kavli Institute of Systems Neuroscience, NTNU.)

 

  • TEACHING ACTIVITIES

 

Current Positions:

2013- Professor of Medicine, Kavli Institute for Systems Neuroscience, NTNU, Trondheim, Norway

2013- Associate Research Professor, University of Oregon, USA

2016-2019- NRSN, Summer school of Norwegian Research School in Neuroscience, organizer

 

Plenary lectures

 

Here is a selection on some of my more recent talks.

 

2019                “6th Heidelberg Forum for Young Life Scientists” Heidelberg University, Germany: June

2019                “The Spring Hippocampal Research Conference” Taormina, Italy: June

2018                 “Kavli Foundation Symposium” in Oslo, Norway. “Memory and cognition”: September

2018                 NIH workshop: “Genetic technologies for systems neuroscience in non-human primates”.

                         Maryland: December     

2018                 “3rd World Congress on Genetics, Geriatrics & Neurodegenerative Diseases Research”.  

                          Toronto, Canada: October

2017                  “Shaping our future”. Science festival in Athens, Greece: April

2016                  “EBPS Memory workshop”. Amsterdam, The Netherlands: September

2015                “Conference on Entorhinal-Hippocampal Complexities”. Janelia Farms, VA: November

2015                  “Spring Hippocampal Research Conference”. Taormina, Italy: June

2014                “9th FENS Forum of neuroscience: on CA2 hippocampus”. Milan, Italy: April

2014                  “Neural & Behavioral Science Seminar NBS”, Røros, Norway: October

2010                 “2nd Workshop on the Computational properties of Prefrontal Cortex” Whistler, CA

2010                “Workshop on Dopamine and Memory, Brandeis University”. Waltham, MA

 

  • ORGANISATION OF SCIENTIFIC MEETINGS

 

2012:     NIH Study Section Member, Molecular Neurogenetics ZRG1 ETTN-H (50)R  

2014:     Member, NIMH Special Emphasis panel ZMH1 ERB-L, BRAIN Initiative, “Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain”. 

2014-:    Swedish Research Council, Young Investigators Panel

 

  • INSTITUTIONAL RESPONSIBILITIES

 

2004-11:            Director of Graduate Core Curriculum, University of Oregon Institute of Neuroscience

2008                  Chair, Congressionally Directed Medical Research Program (CDMRP) Scientific Review panel CTA-Psychological Health/Traumatic Brain Injury.

2010-13:            Cycle Leader, Neural Systems and Behavior Course, Woods Hole, MA       

2014-2018:        Director, Master’s Program in Neuroscience, NTNU, Trondheim, Norway

2019-:                Coordinator of NEVR3002, Systems Neuroscience, NTNU, Trondheim, Norway

 

  • REVIEWING ACTIVITIES

 

20 Selected Publications:

  1. (2018) Nilssen ES, Jacobsen B, Fjeld G, Nair RR, Blankvoort S, Kentros C, Witter MP. Inhibitory connectivity dominates the fan cell network in layer II of lateral entorhinal cortex. Journal of Neuroscience. In press.

  2. (2018) Rowland DC, Obenhaus HA, Skytøen ER, Zhang Q, Kentros CG, Moser EI, Moser MB. Functional properties of stellate cells in medial entorhinal cortex layer II.  Elife. Sep 14;7

  3. (2018) Blankvoort S, Witter MP, Noonan J, Cotney J, Kentros C. Marked Diversity of Unique Cortical Enhancers Enables Neuron-Specific Tools by Enhancer-Driven Gene Expression. Current Biology. Jul 9;28(13):2103-2114

  4. (2017) Tomorsky J, DeBlander L, Kentros CG, Doe CQ, Niell CM. TU-Tagging: A Method for Identifying Layer-Enriched Neuronal Genes in Developing Mouse Visual Cortex. ENEURO. October: 0181-17.

  5. (2017). Kanter BR, Lykken CM, Avesar D, Weible A, Dickinson J, Dunn B, Borgesius NZ, Roudi Y, Kentros CG A Novel Mechanism for the Grid-to-Place Cell Transformation Revealed by Transgenic Depolarization of Medial Entorhinal Cortex Layer II. Neuron Mar 22;93(6):1480-1492

  6. (2014) Weible, A.P., Moore, A.K., Liu, C., DeBlander, L., Wu, H., Kentros, C., Wehr, M.  Perceptual gap detection is mediated by gap termination responses in auditory cortex. Current Biology Jul 7; 24(13):1447-55.

  7. (2014) Moser, E.I., Roudi, Y., Witter, M.P., Kentros, C., Bonhoeffer, T., Moser, M.B..  Grid cells and cortical representation.  Nature Reviews Neuroscience Jul; 15(7):466-81.

  8. (2014) Aikath, D., Weible, A.P., Rowland, D.C., Kentros, C.G.. Role of self-generated odor cues in contextual representation. Hippocampus. Aug; 24(8):1039-51

  9. (2013) Rowland, D., Weible A., Wickersham, I., Wu, H., Seung H. S.,  Mayford, M., Witter, M., Kentros, C. Transgenically-targeted rabies virus demonstrates a major monosynaptic projection from hippocampal area CA2 to medial entorhinal layer II neurons.  Journal of Neuroscience, Sep 11; 33(37):14889-98.

  10. (2012) Weible, A.; Rowland. D.; Pang, R.; Kentros, C.  Neural correlates of long-term object memory in the mouse anterior cingulate cortex.  Journal of Neuroscience Apr 18;32(16):5598-608.

  11. (2012) Garner, A.; Rowland, D.C.; Hwang, S.L.; Baumgarten, K.; Roth, B. L.; Kentros, C.; and Mayford, M.  Generation of a Synthetic Memory Trace.  Science, March 23;335(6075):1513-6.

  12. (2011)  Rowland, D.E.; Yanovich, Y.; and Kentros, C.G.  A stable hippocampal representation of a space requires its direct experience.  Proceedings of the National Academy of Sciences U S A. Aug 30;108(35):14654-8

  13. (2010) Weible, A.*; Schwarz, L.*,Wickersham, I., DeBlander, L., Wu, H., Callaway, E., Seung, S, and  Kentros, C.  Transgenic targeting of recombinant rabies virus reveals neuron-specific connectivity.  Journal of Neuroscience, Dec 8; 30(49):509-13.

  14. (2009)  Wehr, M., Hostick, U., Kyweriga, M., Weible, A., Wu, H., Wu, W., Callaway, E. and Kentros, C. Transgenic Silencing of Neurons in the Mammalian Brain by Expression of the Allatostatin Receptor (AlstR).  Journal of Neurophysiology. Oct;102(4):2554-62

  15. (2009) Weible, A.; Rowland. D.; Pang, R.; Kentros, C.  Neural Correlates of Novel Object and Novel Location Recognition Behavior in the Mouse Anterior Cingulate Cortex.  Journal of Neurophysiology, Oct;102(4):2055-68

  16. (2009) Muzzio,I.A., Kentros, C., and Kandel, E.R.  What is remembered?  Role of Attention on the Encoding and Retrieval of Hippocampal Representations.  Journal of Physiology (London) Jun 15;587(Pt 12):2837-54

  17. (2009) Muzzio, I.A., Levita, L., Kulkarni, J., Monaco J., Kentros C., Stead, M., Abbott, L.F., Kandel, E.R. Attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus. PLoS Biology, Jun 30;7(6)

  18. (2006)  Kentros, C. Hippocampal Place Cells:  the “Where”of Episodic Memory?   Hippocampus,16(9):743-54

  19. (2004) Kentros, C., Agnihotri, N., Streater, S., Hawkins, R.D., Kandel, E.R. “Increased Attention to Spatial Context Increases Both Place Field Stability and Spatial Memory.”  Neuron Apr 22;42(2):283-95

  20. (1998)  Kentros, C., Hargreaves, E., Hawkins, R.D., Kandel, E.R., Shapiro, M. and Muller, R.  Blocking NMDA Receptors Abolishes the Long -Term Stability of a New Hippocampal Place Cell Map of Space.  Science 26 June, 280 2121-2126

  21. (1995) Moreno, H*, Kentros, C*, Bueno, E, Weiser M, Hernandez A, Vega-Saenz de Miera E, Ponce A, Thornhill W, Rudy B Thalamocortical projections have a K+ channel that is phosphorylated and modulated by cAMP-dependent protein kinase. Journal of Neuroscience Aug;15(8):5486-501

 

      Ad Hoc Reviewer:

Journals:  Proceedings of the National Academy of Sciences, Science, Neuroscience, The Journal of        Neuroscience, Hippocampus, Behavioral Neuroscience, Learning and Memory, Cerebral Cortex, Trends in Neuroscience, Journal of Neuroscience Methods, Nature Neuroscience, Neuron, eLife.

Funding Agencies:  National Science Foundation (USA), the Welcome Trust (UK),  New Zealand Research Trust, Advisory Board member for the UK Alzheimer’s Trust.

My Complete Bibliography:

 https://www.ncbi.nlm.nih.gov/pubmed/?term=kentros, c

 

  • MEMBERSHIPS OF SCIENTIFIC SOCIETIES

 

Member, Royal Academy of Arts and Letters, Trondheim, Norway 2015

FENS/Kavli Network of Excellence, 2015

Federation of European Neuroscience, 2015

Norwegian Neuroscience Society, 2015

Society for Neuroscience, 2016

DKNVS, Det Kongelige Norske Vitenskapers Selskap, 2016

 

  • MAJOR COLLABORATIONS

 

 

1) Menno Witter, Professor and heads the functional neuroanatomy research group, started in 2007. He is Director of the Norwegian Research School in Neuroscience. Kavli Institute for Systems Neuroscience, NTNU, Norway

 

2) Justin Cotney, Assistant Professor, Department of Genetics and Genome Sciences at the , University of Connecticut Health Center.

 

3) Jayeeta Basu, Assistant Professor, Department of Neuroscience and Physiology, NYU School of Medicine

 

4) Sarah London, Associate Professor, Department of Psychology, University of Chicago.

 

5) Jin Hyung Lee, Associate Professor of Neurology, Department of Neurosurgery and of Bioengineering, Stanford University. 

 

6) Tristan Schuman, Assistant Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai. 

 

7) Christophe Bernard, Associate Professor,

Aix-Marseille Université | AMU · Institut de Neurosciences des Systèmes, Marseille, France.

 

8) Mark Cembrowski, Assistant Professor, Department of Cellular and Physiological Sciences, University of British Colombia.

 

9) Itamar Kahn, Associate Professor at the Technion’s Ruth and Bruce Rappaport Faculty of Medicine, Technion University, Israel. 

 

10) Dietmar Thal, Professor for Neuropathology Katholieke UniversityLeuven, Belgium.

 

11) Tadashi Isa, Professor at Division of Physiology and Neurobiology, Department of Neuroscience, Kyoto University, Japan.

 

12) Masahiko Takada, Professor of the Primate Research Institute at Kyoto University, Japan.

 

13) Ken-Ichiro Tsutsui, Associate Professor, Tohoku University Graduate School of Life Sciences, Japan.

 

14) Beth Buffalo, Associate Professor, Department of Physiology & Biophysics, University of Washington

 

15) Mark Schnitzer, Professor & Investigator of the Howard Hughes Medical Institute and a Professor at Stanford University.

 

16) Barry Richmond, Investigator at the Section on Neural Coding and Computation (SNCC) Laboratory of Neuropsychology (LN) at NIH, National Institutes of Health Neuroscience.

 

 

Appendix: All ongoing and submitted grants and funding of the PI

 

Current Support:

 

Norwegian Research Council “Toppforsk” Grant, “Enhanced Transgenics: Bioinformatically Informed Design of Transgenic Tools for Systems Neuroscience”. 01/2016 -12/2020, 25,000,000.00 NOK total direct costs.

 

National Institute of Health Grant #1R01MH097130 “Transgenic Dissection of the Neural Circuitry of the Intact Hippocampal Formation.” PI, Funded from 04/2013-04/2019; 2,452,016.00 USD total direct costs. 

 

 

Past Support:

 

Oregon Medical Research Foundation Young Investigator Research Grant: “Pharmacological Modulation of a Hippocampal Representation.” PI, 30,000$ 12/01/06-12/01/07

 

Military Medical Research and Development W81XWH-07-2-0092, co-PI (project PI Dr. Richard Linton). “Generation of BAC transgenic mice capable of specifically expressing

transgenes in the prefrontal cortex and basal forebrain cholinergic nuclei.” 8/15/07-09/14/12, 240,000$/yearly.

 

National Institute of Health Grant# 1R21 MH076289 “The Analysis of Central Neural Circuits by Subtractive Transgenics” PI, Funded 04/01/08-03/31/10; total direct costs 275,000$ over 2 years.

 

National Institute of Health Grant #1RC2NS069464-01 “Tools for Mapping Mammalian Nervous System Connections with Modified Rabies Virus.” Co-PI with Edward Callaway and Martyn Goulding, Salk Institute for Biological Studies, San Diego, CA.  (09/30/2009 - 08/31/2011, our portion 260,000$/yearly direct costs).

 

Pending Support:

 

Norwegian Research Council “Optimisation” BIOTEK 2021 Grant: Development of EDGE viral vectors for cell-specific delivery of therapeutic transgenes for Alzheimer’s and Parkinson’s Disease. 5,600,000.00M NOK over 3 years. Earliest start date June 2018.

 

  • Patents and Inventions:

 

Pending: United States Patent Application No. 62/584,282,
Applicant: Norwegian University of Science and Technology (NTNU)
Title: Neuronal Enhancers

Kavli Institute for Systems Neuroscience

Faculty of Medicine and Health Sciences

NTNU